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Several species of Vernonia, including V. Common names for these species include bitterleaf. Functional use(s) - flavoring agents. Has an woody type odor. Functional use(s) - flavor and fragrance agents. Has a spicy type odor and an spicy type flavor. This is a list of plants used or formerly used as herbal medicine. The ability to synthesize a wide variety of chemical compounds that are used to perform important. A Hooda, M Rathee, J Singh. Chewing Sticks In The Era Of Toothbrush: A Review. The Internet Journal of Family Practice. 2009 Volume 9 Number 2. Following is the list of all articles that will be published in future issues. Click on the article to view it. If you wish to see articles in the previous issues. Internet Scientific Publications. Introduction Chewing sticks are commonly used as oral hygiene tool in various parts of the world. The choice of stick depends largely on traditional preference rather than clinical effectiveness. It is an affordable oral hygiene device and additional benefits are derived form its functional aspect of chewing as jaw exerciser as well as reflex induction of saliva which is beneficial to the oral hygiene. The lower incidence of dental caries amongst users of chewing sticks (compared to non- users) has been attributed to the superior mechanical cleansing action on the teeth and to the antimicrobial properties of some of these sticks. A review of the efficacy and usefulness of chewing sticks in comparison to the toothbrush and toothpaste in dental hygiene is being presented. Review The use of chewing sticks has been documented since ancient times. This kind of tooth brushing has been used by the Babylonians some 7. The use of wood stick for brushing teeth continues to be an important tool in many Afro- Asian communities. It has different names in different societies for instance; miswak, siwak or arak is used in the Middle East, miswaki, in Tanzania, mefaka in Ethiopia and datun in India and Pakistan. The conventional meaning of miswak is stick used to clean teeth and gums. The most commonly used chewing sticks are those having a good flavor, texture and a recognized effect on the teeth and supporting tissue. Freshly cut specimens are always desirable because they are more easily chewed into a brush. The plants used are very carefully selected for such properties as foaminess, hardness or bitterness and certain species are more popular than others. A great number of these plant species have related medicinal properties that may be antibacterial. Plants Commonly Used as Chewing Sticks Popular plants which are fascinated into chewing and/or tooth brushing sticks include Salvadora persica (miswak from arak tree) and Azadirachta indica (Neem). Some of the popular species used as natural toothbrush in Southern- Eastern Africa are Albizia coriaria, Acacia nilotica, Balanites aegyptiaca, Berchemia discolor, Boscia coriacea, Cadaba farinose, Cordia sinensis, Cupressus lusitanica, Dobera glabra, Dodonia angustifolia, Euclea schimperi, Olea europea subsp. In West Africa the lime tree (Citrus aurantafolia) and the orange tree (Citrus sinesis) are used. The roots of Senna (Cassia vinnea) were used by black Americans and those of African laburnum (Cassia sieberianba) were used in Sierra Leone. Arak, a tree used for miswak, is also known as “tooth brush tree”. Although the Miswak is usually obtained from the roots of the Arak tree, some sticks are made from its branches and bark. Indian Plants Commonly Used as Chewing Sticks In India plant wealth is greatly exploited for its therapeutic potential and medicinal efficacy to cure various oral ailments since time immemorial. Neem (Azadirachta indica) is widely used to provide chewing sticks in the Indian subcontinent. Tripathi has documented various plants being used in oral health care as chewing sticks (dantun) by the rural population of India. Some plants have been listed in Table- I. These are still used to clean the teeth as chewing sticks. These plants possess antiseptic, antibacterial, antifungal, astringent, styptic, anti- inflammatory, sialogogue, antiviral as well as anti- carious properties. Mechanism of Action Miswak is generally used for a longer period of time than is a modern toothbrush and the cleaning is usually implemented for 5 to 1. The plant fibers remove plaque and simultaneously massage the gums. Cleansing efficacy of miswak is attributed to the mechanical effects of its fibers, release of beneficial chemicals or a combination of both . Further it stimulates salivation and thus there may be a better cleansing effect. Some African chewing sticks are also reported to contain fluoride ions, silicon, tannic acid, sodium bicarbonate and other natural plaque inhibiting substances that can reduce bacterial colonization and plaque formation. Chemically, the air dried stem bark of S. Alkaloids exert bactericidal effect in the oral cavity. Essential (volatile) oils possess characteristic aroma and exert antiseptic action. The mild bitter taste stimulates the flow of saliva, which is antiseptic. The sulfur compounds have a bactericidal effect. Vitamin C is antioxidant and helps in the healing and repair of tissues. Sodium bicarbonate has mild abrasive properties and is, thus, used as a dentifrice in addition to having a mild germicidal action. The high concentrations of chloride inhibit calculus formation. Calcium saturation of saliva inhibits demineralization and promotes re- mineralization of tooth enamel. The root of Salvadora persica contains a steam- distillable oil composed of 1. Benzylisothiocyanate (BIT). BIT is classified as one of the chemo- preventive agents that are thought to prevent carcinogenic and other genotoxic compounds from reaching or reacting with the target sites on the treated tissue. BIT is reported to have a virucidal activity against herpes simplex virus- I (HSV- I) at a concentration of 1. In addition, it has been shown to possess a broad- spectrum bactericidal activity. Al- Lafi et al reported that BIT inhibits the growth and acid production of streptococcus mutans. Effect on Dental Plaque It is claimed that the mechanical plaque- removing properties of chewing sticks may be similar to that of a conventional toothbrush . Al- Otaibi et al 2. Further they state that miswak appeared to be more effective than tooth brushing for removing plaque from the embrasures, thus enhancing inter- proximal health. Various other studies have also demonstrated the usefulness of chewing sticks. Hardie and Ahmed stated that the plaque removing properties of miswak and conventional tooth brushes are similar. Ndungv et al studied the efficacy of chewing stick and concluded that patients with severe plaque deposition, the tooth brush is more efficacious than the chewing stick in plaque control. However, for patients with moderate plaque deposits, the chewing stick is as efficacious as the tooth brush in plaque control. The bitter leaf plant is known as Elewuro by the Yorubas, Shuwaka by the Hausas and Onugbu by the Igbo people. Bitter leaf has a great healing potency. Xylopia aethiopica, commonly called African pepper or Guinea pepper belongs to the family Annonaceae. In Nigerian, it is called kyimba in Arabic, kumba in Arabic. Danielsen et al assessed the efficacy of brushing with chewing sticks on plaque removal and concludes that brushing with a chewing stick for five minutes resulted in a net reduction of the proportions of plaque deposit sites per child and the tooth paste resulted in no additional effect. Helderman et al compared the oral hygiene of habitual chewing stick and tooth brush used in children in the age group of 1. They reported that though at baseline, chewing stick user exhibit statistically significant more plaque, but their gingival condition was comparable with tooth brush users. Further at three months, the chewing stick and the tooth brush users had reduced their plaque and gingival bleeding scores significantly to the same extent. The authors suggest that effective tooth brushing was helpful to improve oral hygiene regardless of whether chewing stick or tooth brush is used. Effect on Periodontal Health Eid and Selim examined the relationship between miswak and gingival health in terms of pocket depths, periodontal disease severity and gingival recession in 2. They suggested that the use of miswak may influence periodontal health and may be considered as a contributing factor to gingival recession. Nortan and Addey recorded the oral hygiene and gingival health of adult Ghanians who used chewing sticks, tooth brushes or a combination of both for tooth cleaning. Plaque and gingivitis scores were higher in chewing sticks users. They further reported that men had poorer oral hygiene and gingival health than women, irrespective of oral hygiene regimen. They suggested that longer time is necessary for the cleaning with chewing sticks may explain the apparent reduced cleaning efficiency in men. They also concluded that the antimicrobial substances in chewing sticks appear to provide no additional benefits to those produced by the antimicrobial activity of commercially available toothpastes. Rinsing with slurry of miswak toothpaste reduces gingival inflammation and bleeding on probing. Chlorhexidine and miswak were compared and chlorhexidine (CHX) was found to be more effective than miswak in plaque reduction. It was found that streptococcus mutants were eliminated in the miswak group and were less in CHX. Gazi et al. 37 reported that plaque and gingivitis were significantly reduced when miswak was used 5 times a day compared with conventional toothbrush. Guile et al concluded from a survey of Saudi school children that the low incidence of periodontal disease was attributable to the practice of using miswak for teeth cleaning. In general, it is concluded from the above- mentioned studies that reduction in plaque leads to a decrease in gingivitis and ultimately a reduction in bleeding from the gums. Antibacterial Activity Miswak has got antibacterial activities. Almas and Al- Zeid tested the antimicrobial activity of Salvadora persica in vivo on Streptococcus mutans and Lactobacilli. There was a marked reduction of Streptococcus mutans among all groups. When the groups were compared, the reduction of Streptoccus mutans was significantly greater using miswak in comparison to tooth brushing and there was no significant difference for Lactobacilli reduction. Almas compared the effectiveness of antimicrobial activity of Salvadora persica (Arak) and Azadirachta indica (Neem ) chewing sticks extracts at various concentrations. The p. H of neem and arak extract was 6. The authors reported that both chewing stick extracts were effective at 5. Streptococcus mutans and Streptococcus faecalis. Arak extract was more effective at lower concentrations for Streptococcus faecalis. Taiwo et al studied the antibacterial activity of 1. Nigeria against 2. Click on the article to view it. If you wish to see articles in the previous issues Click Here. Role of GAD peptides p. INS receptor in salivary tissues of type 1 diabetic mice (Vol. No. 5, September 2. Page No: 0. 0By: Rodrigo Eduardo da Silva, Nilva de Karla Cervigne, Clovis Antonio Lopes Pinto, Marcelo Rodrigues da Cunha, Fernanda Rojas, Luis Antonio Peroni, Taize Machado Augusto, Evaldo Marchi, Barkat Ali Khan, Eduardo Jos. Development and evaluation of novel antihypertensive orodispersible tablets (Vol. No. 5, September 2. Page No: 0. 0By: Hafeez ullah Khan, Muhammad Hanif, Rai M Sarfraz, Safirah Maheen, Samina Afzal, Muhammad Sher, Khurram Afzal, Asif Mahmood, Ayesha Shamim. Synthesis, antinociceptive activity and structure activity relationship of flavone derivatives (Vol. No. 5, September 2. 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